BAHÇEŞEHİR UNIVERSITY BİLGİ PAKETİ / DERS KATALOĞU
| MOLECULAR BIOLOGY AND GENETICS | |||||
| Bachelor | TR-NQF-HE: Level 6 | QF-EHEA: First Cycle | EQF-LLL: Level 6 | ||
Course Introduction and Application Information
| Course Code | Course Name | Semester | Theoretical | Practical | Credit | ECTS |
| MBG4066 | Cancer Genetics and Biology | Fall | 3 | 0 | 3 | 6 |
| This catalog is for information purposes. Course status is determined by the relevant department at the beginning of semester. |
Basic information
| Language of instruction: | English |
| Type of course: | Departmental Elective |
| Course Level: | Bachelor’s Degree (First Cycle) |
| Mode of Delivery: | Face to face |
| Course Coordinator : | Dr. Öğr. Üyesi ELIZABETH HEMOND |
| Course Objectives: | In this course, student should learn about genetic changes in cancer, phenotype of cancer cells, oncogenes, tumor suppressor genes, hereditary cancers, cell cycle, apoptosis, senescence, DNA repair and cancer, multicellular interactions in cancer. |
Learning Outcomes
|
The students who have succeeded in this course; 1. Have a general knowledge on genetic changes induced by cancer. 2. Discuss terms of oncogene and tumor suppressor gene. 3. Understand hereditary cancers and DNA repair cancer relationship. 4. Discuss cell cycle, apoptosis and multicellular cell interactions in cancer. |
Course Content
| Genetic changes in cancer, phenotype of cancer cells, oncogenes, tumor suppressor genes, hereditary cancers, cell cycle, apoptosis, senescence, DNA repair and cancer, multicellular interactions in cancer. |
Weekly Detailed Course Contents
| Week | Subject | Related Preparation |
| 1) | Cancer as a disease | |
| 2) | Model organisms and techniques used in cancer studies | |
| 3) | Mutated genomes of cancer cells, DNA gains, DNA losses and nucleotide changes | |
| 4) | Epigenetic changes in cancer cells | |
| 5) | Viral and cellular oncogenes | |
| 6) | Tumor suppressor genes | |
| 7) | Overview of phenotypic changes in cancer cells | |
| 8) | Cell cycle and cancer | |
| 9) | DNA damage response in cancer cells | |
| 10) | DNA repair and cancer | |
| 11) | Senescence aberrations in cancer cells | |
| 12) | Apoptotic and autophagic aberrations in cancer cells | |
| 13) | Invasive and metastatic abilities of cancer cells | |
| 14) | Tumor heterogeneity and "cancer stem cells" |
Sources
| Course Notes / Textbooks: | The Molecular Basis of Cancer.2nd edition Author(s): Mendelsohn, Howley, Israel & Liotta. Publisher: W. B. Saunders Company, Philadelphia, 2011 |
| References: | The Genetic Basis of Human Cancer Author(s): B. Vogelstein & K. W. Kinzler Publisher: McGraw-Hill, New York, 1999 |
Evaluation System
| Semester Requirements | Number of Activities | Level of Contribution |
| Attendance | 10 | % 5 |
| Homework Assignments | 1 | % 15 |
| Midterms | 1 | % 30 |
| Final | 1 | % 50 |
| Total | % 100 | |
| PERCENTAGE OF SEMESTER WORK | % 50 | |
| PERCENTAGE OF FINAL WORK | % 50 | |
| Total | % 100 | |
ECTS / Workload Table
| Activities | Number of Activities | Duration (Hours) | Workload |
| Course Hours | 14 | 3 | 42 |
| Study Hours Out of Class | 14 | 8 | 112 |
| Midterms | 1 | 2 | 2 |
| Final | 1 | 2 | 2 |
| Total Workload | 158 | ||
Contribution of Learning Outcomes to Programme Outcomes
| No Effect | 1 Lowest | 2 Low | 3 Average | 4 High | 5 Highest |
| Program Outcomes | Level of Contribution | |
| 1) | Utilize the wealth of information stored in computer databases to answer basic biological questions and solve problems such as diagnosis and treatment of diseases. | 5 |
| 2) | Acquire an ability to compile and analyze biological information, clearly present and discuss the conclusions, the inferred knowledge and the arguments behind them both in oral and written format. | 4 |
| 3) | Develop critical, creative and analytical thinking skills. | 5 |
| 4) | Develop effective communication skills and have competence in scientific speaking, reading and writing abilities in English and Turkish. | 5 |
| 5) | Gain knowledge of different techniques and methods used in genetics and acquire the relevant laboratory skills. | 2 |
| 6) | Detect biological problems, learn to make hypothesis and solve the hypothesis by using variety of experimental and observational methods. | 5 |
| 7) | Gain knowledge of methods for collecting quantitative and qualitative data and obtain the related skills. | 3 |
| 8) | Conduct research through paying attention to ethics, human values and rights. Pay special attention to confidentiality of information while working with human subjects. | 5 |
| 9) | Obtain basic concepts used in theory and practices of molecular biology and genetics and establish associations between them. | 4 |
| 10) | Search and use literature to improve himself/herself and follow recent developments in science and technology. | 4 |
| 11) | Be aware of the national and international problems in the field and search for solutions. | 3 |