| MOLECULAR BIOLOGY AND GENETICS | |||||
| Bachelor | TR-NQF-HE: Level 6 | QF-EHEA: First Cycle | EQF-LLL: Level 6 | ||
| Course Code | Course Name | Semester | Theoretical | Practical | Credit | ECTS |
| MBG4066 | Cancer Genetics and Biology | Fall | 3 | 0 | 3 | 6 |
| This catalog is for information purposes. Course status is determined by the relevant department at the beginning of semester. |
| Language of instruction: | English |
| Type of course: | Departmental Elective |
| Course Level: | Bachelor’s Degree (First Cycle) |
| Mode of Delivery: | Face to face |
| Course Coordinator : | Assist. Prof. DİLEK ÇEVİK |
| Course Objectives: | The course will provide the student with a comprehensive insight into the molecular biology and genetics of cancer with an awareness of the complexity of cancer biology. Lectures will primarily focus on the role of growth factors, oncogenes, tumor suppressor and cell stress mechanisms such as apoptosis, senescence, and autophagy. The fundamental principles behind cancer diagnosis, prevention, and targeted molecular therapy will also be discussed. Recent articles regarding cancer will be studied and students will present a subject of interest regarding cancer. |
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The students who have succeeded in this course; 1. Understand the molecular and cellular mechanisms leading to cancer. 2. Describe the genetic event causing oncogenesis. 3. Discuss hallmarks of cancer and cellular stress mechanisms. 4. Discuss cell cycle, apoptosis, and multicellular interactions in cancer. 5. Describe the fundamental principles behind molecular cancer diagnosis. 6. Have an overview of methodologies used in cancer research. 7. Read and discuss cancer related research articles. |
| Genetic changes in cancer, phenotype of cancer cells, oncogenes, tumor suppressor genes, hereditary cancers, cell cycle, apoptosis, senescence, DNA repair and cancer, multicellular interactions in cancer. |
| Week | Subject | Related Preparation |
| 1) | Cancer Epidemiology and Terminology | Reading the Chapter notes |
| 2) | The Nature of Cancer | Reading the chapter notes |
| 3) | Cancer as an Infectious Disease | Reading the chapter notes |
| 4) | Oncogenes | Reading the chapter notes |
| 5) | Tumor Suppressor Genes | Reading the chapter notes |
| 6) | pRB and Control of Cell Cycle Clock | Reading the chapter notes |
| 7) | p53 and Cancer | Reading the chapter notes |
| 8) | DNA damage response in cancer cells | Reading the chapter notes |
| 10) | DNA repair and cancer | Reading the chapter notes |
| 11) | Senescence aberrations in cancer cells | Reading the chapter notes |
| 12) | Apoptotic and autophagic aberrations in cancer cells | Reading the chapter notes |
| 13) | Article Discussions and Student presentations | Reading the articles to be presented before class. |
| 14) | Article Discussions and Student presentations | Reading the articles to be presented before class. |
| Course Notes / Textbooks: | Course Book: The Biology of Cancer, 3rd Edition by Robert Weinberg. Öğrencilere okuma materyali olarak bilimsel makaleler verilecektir. |
| References: | Course Book: The Biology of Cancer, 3rd Edition by Robert Weinberg. Scientific articles will also be assigned to students as reading material. |
| Semester Requirements | Number of Activities | Level of Contribution |
| Homework Assignments | 1 | % 5 |
| Presentation | 1 | % 10 |
| Midterms | 1 | % 30 |
| Final | 1 | % 50 |
| Paper Submission | 1 | % 5 |
| Total | % 100 | |
| PERCENTAGE OF SEMESTER WORK | % 50 | |
| PERCENTAGE OF FINAL WORK | % 50 | |
| Total | % 100 | |
| Activities | Number of Activities | Duration (Hours) | Workload |
| Course Hours | 14 | 3 | 42 |
| Study Hours Out of Class | 14 | 4 | 56 |
| Presentations / Seminar | 1 | 10 | 10 |
| Project | 1 | 10 | 10 |
| Homework Assignments | 1 | 10 | 10 |
| Midterms | 1 | 3 | 3 |
| Paper Submission | 1 | 10 | 10 |
| Final | 1 | 3 | 3 |
| Total Workload | 144 | ||
| No Effect | 1 Lowest | 2 Low | 3 Average | 4 High | 5 Highest |
| Program Outcomes | Level of Contribution | |
| 1) | Acquire an ability to compile and analyze biological information, clearly present and discuss the conclusions, the inferred knowledge and the arguments behind them both in oral and written format. | 5 |
| 2) | Utilize the wealth of information stored in computer databases to answer basic biological questions and solve problems such as diagnosis and treatment of diseases. | 4 |
| 3) | Develop critical, creative and analytical thinking skills. | 5 |
| 4) | Develop effective communication skills and have competence in scientific speaking, reading and writing abilities in English and Turkish. | 5 |
| 5) | Gain knowledge of different techniques and methods used in genetics and acquire the relevant laboratory skills. | 2 |
| 6) | Detect biological problems, learn to make hypothesis and solve the hypothesis by using variety of experimental and observational methods. | 5 |
| 7) | Gain knowledge of methods for collecting quantitative and qualitative data and obtain the related skills. | 3 |
| 8) | Conduct research through paying attention to ethics, human values and rights. Pay special attention to confidentiality of information while working with human subjects. | 5 |
| 9) | Obtain basic concepts used in theory and practices of molecular biology and genetics and establish associations between them. | 4 |
| 10) | Search and use literature to improve himself/herself and follow recent developments in science and technology. | 4 |
| 11) | Be aware of the national and international problems in the field and search for solutions. | 3 |