MOLECULAR BIOLOGY AND GENETICS
Bachelor	TR-NQF-HE: Level 6	QF-EHEA: First Cycle	EQF-LLL: Level 6

Course Introduction and Application Information

Course Code	Course Name	Semester	Theoretical	Practical	Credit	ECTS
BNG5111	Concepts and Applications in Biomedical Engineering	Spring	3	0	3	8

This catalog is for information purposes. Course status is determined by the relevant department at the beginning of semester.

Basic information

Language of instruction:	English
Type of course:	Departmental Elective
Course Level:	Bachelor’s Degree (First Cycle)
Mode of Delivery:	Face to face
Course Coordinator :	Prof. Dr. GÜLAY BULUT
Recommended Optional Program Components:	There is none.
Course Objectives:	Providing theoretical and practical information about the engineering aspects of biotechnological processes.

Learning Outcomes

The students who have succeeded in this course;
1) Ability to make necessary calculations regarding to yield and productivity
2) To take interest in new approaches of commercial applications of biotechnological processes.
3) Ability to understand the bioconversions and bioconversion kinetics.
4) Comprehend the importance and application range of microorganism, plant and animal cells in biotechnology applications.
5)Fundamental conception informations of microorganism, plant and animal cell culture techniques.

Course Content

1. Basic components of cell culture systems (Cell structure, cell growth, differentiation transformation, ageing) 2. Cell growth media (Basic composition of media, effect of culture system on medium design, medium preparation, sterilization, quality control) 3. Sources of the cell line cultures 4. Contamination of cell cultures Sources, concequences, prevention and elimination) 5. Plant cell and tissue cultures (Definitions, culture media and conditions) 6. Plant cell and tissue culture methods, application areas 7. Secondary metabolites produced by plant cell and tissue cultures 8. Callus cultures and in vitro selection 9. Bioprocess kinetics 10. Mathematical modeling and estimation of the performance 11. Definitions of yield and productivity 12. Types of biocatalysts 13. Bioreactors

Weekly Detailed Course Contents

Week	Subject	Related Preparation
1)	Basic components of cell culture systems (cell structure, cell growth, differentiation transformation, ageing).
2)	Cell growth media (Basic composition of media, effect of culture system on medium design, medium preparation, sterilization, quality control).
3)	Sources of the cell line cultures.
4)	Contamination of cell cultures sources, concequences, prevention and elimination).
5)	Plant cell and tissue cultures (definitions, culture media and conditions).
6)	Secondary metabolites produced by plant cell and tissue cultures.
7)	In vitro selection by plant cell and tissue cultures.
8)	Production disease free plant material.
9)	Mathematical modeling and estimation of the performance I
10)	Mathematical modeling and estimation of the performance II
11)	Types of biocatalysts. Definitions of yield and productivity I
12)	Types of biocatalysts. Definitions of yield and productivity II
13)	Bioreactors. Working systems of bioreactors I
14)	Bioreactors. Working systems of bioreactors II

Sources

Course Notes / Textbooks:

Griffiths, J. B., 1990. Animal Cell Biotechnology, Vol 1-4; Eds. R. E. Spier, Acad. Pres Inc. Freshney I. R. 1994. Culture of Animal Cells. Wiley Liss Inc. Neumann, K., H., A.Kumar, J. Imani, 2009. Plant Cell and Tissue Culture – A Tool in Biotechnology; Basics and Application. Springer – Verlag , Berlin Heidelberg. George, E. F., M.A. Hall, G.-J.De Klerk, 2008. Plant Propagation by Tissue Culture. 3rd Edition Volume 1. Springer Publishing Company. Loyola-Vargas, V.M., F. Vázquez-Flota, 2006. Plant Cell Culture Protocols, Second Edition, Humana Press Inc. Bailey, J. E., D. F. Ollis, 1986. Biochemical Engineering Fundamentals, McGraw Hill.

References:

Evaluation System

Semester Requirements	Number of Activities	Level of Contribution
Attendance	1	% 10
Midterms	1	% 30
Final	1	% 60
Total		% 100
PERCENTAGE OF SEMESTER WORK		% 40
PERCENTAGE OF FINAL WORK		% 60
Total		% 100

ECTS / Workload Table

Activities	Number of Activities	Duration (Hours)	Workload
Course Hours	14	4	56
Study Hours Out of Class	14	7	98
Midterms	1	20	20
Final	1	30	30
Total Workload			204

Contribution of Learning Outcomes to Programme Outcomes

No Effect	1 Lowest	2 Low	3 Average	4 High	5 Highest

	Program Outcomes	Level of Contribution
1)	Utilize the wealth of information stored in computer databases to answer basic biological questions and solve problems such as diagnosis and treatment of diseases.	5
2)	Acquire an ability to compile and analyze biological information, clearly present and discuss the conclusions, the inferred knowledge and the arguments behind them both in oral and written format.	5
3)	Develop critical, creative and analytical thinking skills.	5
4)	Develop effective communication skills and have competence in scientific speaking, reading and writing abilities in English and Turkish.	4
5)	Gain knowledge of different techniques and methods used in genetics and acquire the relevant laboratory skills.	4
6)	Detect biological problems, learn to make hypothesis and solve the hypothesis by using variety of experimental and observational methods.	5
7)	Gain knowledge of methods for collecting quantitative and qualitative data and obtain the related skills.	3
8)	Conduct research through paying attention to ethics, human values and rights. Pay special attention to confidentiality of information while working with human subjects.	3
9)	Obtain basic concepts used in theory and practices of molecular biology and genetics and establish associations between them.	5
10)	Search and use literature to improve himself/herself and follow recent developments in science and technology.	4
11)	Be aware of the national and international problems in the field and search for solutions.	4