ARTIFICIAL INTELLIGENCE ENGINEERING
Bachelor	TR-NQF-HE: Level 6	QF-EHEA: First Cycle	EQF-LLL: Level 6

Course Introduction and Application Information

Course Code	Course Name	Semester	Theoretical	Practical	Credit	ECTS
MBG4066	Cancer Genetics and Biology	Spring	3	0	3	6

This catalog is for information purposes. Course status is determined by the relevant department at the beginning of semester.

Basic information

Language of instruction:	English
Type of course:	Non-Departmental Elective
Course Level:	Bachelor’s Degree (First Cycle)
Mode of Delivery:	Face to face
Course Coordinator :	Dr. Öğr. Üyesi ELIZABETH HEMOND
Course Objectives:	In this course, student should learn about genetic changes in cancer, phenotype of cancer cells, oncogenes, tumor suppressor genes, hereditary cancers, cell cycle, apoptosis, senescence, DNA repair and cancer, multicellular interactions in cancer.

Learning Outcomes

The students who have succeeded in this course;
1. Have a general knowledge on genetic changes induced by cancer.
2. Discuss terms of oncogene and tumor suppressor gene.
3. Understand hereditary cancers and DNA repair cancer relationship.
4. Discuss cell cycle, apoptosis and multicellular cell interactions in cancer.

Course Content

Genetic changes in cancer, phenotype of cancer cells, oncogenes, tumor suppressor genes, hereditary cancers, cell cycle, apoptosis, senescence, DNA repair and cancer, multicellular interactions in cancer.

Weekly Detailed Course Contents

Week	Subject	Related Preparation
1)	Cancer as a disease
2)	Model organisms and techniques used in cancer studies
3)	Mutated genomes of cancer cells, DNA gains, DNA losses and nucleotide changes
4)	Epigenetic changes in cancer cells
5)	Viral and cellular oncogenes
6)	Tumor suppressor genes
7)	Overview of phenotypic changes in cancer cells
8)	Cell cycle and cancer
9)	DNA damage response in cancer cells
10)	DNA repair and cancer
11)	Senescence aberrations in cancer cells
12)	Apoptotic and autophagic aberrations in cancer cells
13)	Invasive and metastatic abilities of cancer cells
14)	Tumor heterogeneity and "cancer stem cells"

Sources

Course Notes / Textbooks:	The Molecular Basis of Cancer.2nd edition Author(s): Mendelsohn, Howley, Israel & Liotta. Publisher: W. B. Saunders Company, Philadelphia, 2011
References:	The Genetic Basis of Human Cancer Author(s): B. Vogelstein & K. W. Kinzler Publisher: McGraw-Hill, New York, 1999

Evaluation System

Semester Requirements	Number of Activities	Level of Contribution
Attendance	10	% 5
Homework Assignments	1	% 15
Midterms	1	% 30
Final	1	% 50
Total		% 100
PERCENTAGE OF SEMESTER WORK		% 50
PERCENTAGE OF FINAL WORK		% 50
Total		% 100

ECTS / Workload Table

Activities	Number of Activities	Duration (Hours)	Workload
Course Hours	14	3	42
Study Hours Out of Class	14	8	112
Midterms	1	2	2
Final	1	2	2
Total Workload			158

Contribution of Learning Outcomes to Programme Outcomes

No Effect	1 Lowest	2 Low	3 Average	4 High	5 Highest

	Program Outcomes	Level of Contribution
1)	Have sufficient background in mathematics, science and artificial intelligence engineering.
2)	Use theoretical and applied knowledge in the fields of mathematics, science and artificial intelligence engineering together for engineering solutions.
3)	Identify, define, formulate and solve engineering problems, select and apply appropriate analytical methods and modeling techniques for this purpose.
4)	Analyse a system, system component or process and design it under realistic constraints to meet desired requirements; apply modern design methods in this direction.
5)	Select and use modern techniques and tools necessary for engineering applications.
6)	Design and conduct experiments, collect data, and analyse and interpret results.
7)	Work effectively both as an individual and as a multi-disciplinary team member.
8)	Access information via conducting literature research, using databases and other resources
9)	Follow the developments in science and technology and constantly update themself with an awareness of the necessity of lifelong learning.
10)	Use information and communication technologies together with computer software with at least the European Computer License Advanced Level required by their field.
11)	Communicate effectively, both verbal and written; know a foreign language at least at the European Language Portfolio B1 General Level.
12)	Have an awareness of the universal and social impacts of engineering solutions and applications; know about entrepreneurship and innovation; and have an awareness of the problems of the age.
13)	Have a sense of professional and ethical responsibility.
14)	Have an awareness of project management, workplace practices, employee health, environment and work safety; know the legal consequences of engineering practices.