BIOMEDICAL ENGINEERING
Bachelor TR-NQF-HE: Level 6 QF-EHEA: First Cycle EQF-LLL: Level 6

Course Introduction and Application Information

Course Code Course Name Semester Theoretical Practical Credit ECTS
BME4005 Laser-Tissue Interactions Fall 3 0 3 7
The course opens with the approval of the Department at the beginning of each semester

Basic information

Language of instruction: En
Type of course: Departmental Elective
Course Level: Bachelor
Mode of Delivery: Face to face
Course Coordinator : Dr. Öğr. Üyesi BURCU TUNÇ ÇAMLIBEL
Course Objectives: The aim of this course is to provide a thorough understanding of the basic physical principles which underlie therapeutic uses of lasers in medicine. Laser-tissue interaction mechanisms will be examined.

Learning Outputs

The students who have succeeded in this course;
On completion successful students will be able to understand the mechanisms describing the interaction of laser radiation with biological tissue, spectroscopic and diagnostic optical applications of lasers in medicine, selected applications of lasers and optical techniques which are presently important in medicine.

Course Content

Wave motion, electromagnetic theory, electromagnetic spectrum, propagation of light , measurement of optical properties of tissues, optics, microscopy, lasers, mechanisms of laser-tissue ineractions, lasers in surgery, tissue welding, laser tweezers, lasers in imaging, diagnostic applications, electrosurgery versus laser surgery, laser safety.

Weekly Detailed Course Contents

Week Subject Related Preparation
1) Introduction, wave motion; plane, spherical and cylindrical waves, Electromagnetic theory, electromagnetic waves, energy and momentum of radiation. Dipole emission, emission and absorption by atoms and molecules, black body radiation, electromagnetic spectrum.
2) Propagation of light: reflection, refraction, scattering, interference and diffraction. Measurement of optical properties of tissue, Geometrical optics, fiberoptics. Microscopy and limits of resolution, mechanisms of contrast.
3) Eye and vision, perception of color. Spontaneous and stimulated emission, principle of laser, cavity modes, lasing media, pumping mechanisms, continuous and pulsed regimes.
4) "Mechanisms of laser-tissue interactions I: Photochemical. Photodynamic therapy, photostimulation, cytotoxicity of UV light."
5) Mechanisms of laser-tissue interactions II: Photothermal. Heat generation, heat conduction and distribution. Thermal damage to tissue. Laser-Induced Interstitial Thermotherapy (LIIT).
6) Mechanisms of laser-tissue interactions III: Photomechanical. Explosive evaporation, shock and acoustic waves, cavitation, jet formation.
7) Mechanisms of laser-tissue interactions IV: Dielectric breakdown, plasma-mediated ablation.
8) Lasers in Ophthalmology.
9) Lasers in Dermatology.
10) Lasers in General Surgery, Cardiovascular Surgery, Gynecology. Tissue welding. Low power lasers. Micromanipulation and cell surgery.
11) Lasers in Imaging.
12) Diagnostic applications: Autofluorescence, Raman spectroscopy, Scattering Light Spectroscopy, Doppler velocimetry.
13) "Electrosurgery: Mechanisms of interaction and tissue damage. Pros and cons vs. laser surgery."
14) Laser safety: lasers classification.

Sources

Course Notes: M. H. Niemz, Laser tissue interactions, Springer Verlag. ISBN 354-060-3638
References: Lasers in Medical Science (SpringerLINK 1998-), Lasers in Surgery and Medicine (WILEY 1997-)

Evaluation System

Semester Requirements Number of Activities Level of Contribution
Attendance 0 % 0
Laboratory 0 % 0
Application 0 % 0
Field Work 0 % 0
Special Course Internship (Work Placement) 0 % 0
Quizzes 0 % 0
Homework Assignments 0 % 0
Presentation 1 % 40
Project 0 % 0
Seminar 0 % 0
Midterms % 0
Preliminary Jury 0 % 0
Final 1 % 60
Paper Submission 0 % 0
Jury 0 % 0
Bütünleme % 0
Total % 100
PERCENTAGE OF SEMESTER WORK % 40
PERCENTAGE OF FINAL WORK % 60
Total % 100

ECTS / Workload Table

Activities Number of Activities Duration (Hours) Workload
Course Hours 14 3 42
Laboratory 0 0 0
Application 0 0 0
Special Course Internship (Work Placement) 0 0 0
Field Work 0 0 0
Study Hours Out of Class 14 8 112
Presentations / Seminar 0 0 0
Project 0 0 0
Homework Assignments 0 0 0
Quizzes 0 0 0
Preliminary Jury 0 0 0
Midterms 2 2 4
Paper Submission 0 0 0
Jury 0 0 0
Final 1 2 2
Total Workload 160

Contribution of Learning Outcomes to Programme Outcomes

No Effect 1 Lowest 2 Low 3 Average 4 High 5 Highest
           
Program Outcomes Level of Contribution
1) Adequate knowledge of subjects specific to mathematics (analysis, linear, algebra, differential equations, statistics), science (physics, chemistry, biology) and related engineering discipline, and the ability to use theoretical and applied knowledge in these fields in complex engineering problems.
2) Identify, formulate, and solve complex Biomedical Engineering problems; select and apply proper modeling and analysis methods for this purpose
3) Design complex Biomedical systems, processes, devices or products under realistic constraints and conditions, in such a way as to meet the desired result; apply modern design methods for this purpose.
4) Devise, select, and use modern techniques and tools needed for solving complex problems in Biomedical Engineering practice; employ information technologies effectively.
5) Design and conduct numerical or physical experiments, collect data, analyze and interpret results for investigating the complex problems specific to Biomedical Engineering.
6) Cooperate efficiently in intra-disciplinary and multi-disciplinary teams; and show self-reliance when working on Biomedical Engineering-related problems.
7) Ability to communicate effectively in Turkish, oral and written, to have gained the level of English language knowledge (European Language Portfolio B1 general level) to follow the innovations in the field of Biomedical Engineering; gain the ability to write and understand written reports effectively, to prepare design and production reports, to make effective presentations, to give and receive clear and understandable instructions.
8) Recognize the need for life-long learning; show ability to access information, to follow developments in science and technology, and to continuously educate oneself.
9) Having knowledge for the importance of acting in accordance with the ethical principles of biomedical engineering and the awareness of professional responsibility and ethical responsibility and the standards used in biomedical engineering applications
10) Learn about business life practices such as project management, risk management, and change management; develop an awareness of entrepreneurship, innovation, and sustainable development.
11) Acquire knowledge about the effects of practices of Biomedical Engineering on health, environment, security in universal and social scope, and the contemporary problems of Biomedical Engineering; is aware of the legal consequences of Mechatronics engineering solutions.