| MATHEMATICS (TURKISH, PHD) | |||||
| PhD | TR-NQF-HE: Level 8 | QF-EHEA: Third Cycle | EQF-LLL: Level 8 | ||
| Course Code | Course Name | Semester | Theoretical | Practical | Credit | ECTS |
| MBG4066 | Cancer Genetics and Biology | Fall | 3 | 0 | 3 | 6 |
| The course opens with the approval of the Department at the beginning of each semester |
| Language of instruction: | En |
| Type of course: | Departmental Elective |
| Course Level: | |
| Mode of Delivery: | Face to face |
| Course Coordinator : | Dr. Öğr. Üyesi ELIZABETH HEMOND |
| Course Objectives: | In this course, student should learn about genetic changes in cancer, phenotype of cancer cells, oncogenes, tumor suppressor genes, hereditary cancers, cell cycle, apoptosis, senescence, DNA repair and cancer, multicellular interactions in cancer. |
|
The students who have succeeded in this course; 1. Have a general knowledge on genetic changes induced by cancer. 2. Discuss terms of oncogene and tumor suppressor gene. 3. Understand hereditary cancers and DNA repair cancer relationship. 4. Discuss cell cycle, apoptosis and multicellular cell interactions in cancer. |
| Genetic changes in cancer, phenotype of cancer cells, oncogenes, tumor suppressor genes, hereditary cancers, cell cycle, apoptosis, senescence, DNA repair and cancer, multicellular interactions in cancer. |
| Week | Subject | Related Preparation | |
| 1) | Cancer as a disease | ||
| 2) | Model organisms and techniques used in cancer studies | ||
| 3) | Mutated genomes of cancer cells, DNA gains, DNA losses and nucleotide changes | ||
| 4) | Epigenetic changes in cancer cells | ||
| 5) | Viral and cellular oncogenes | ||
| 6) | Tumor suppressor genes | ||
| 7) | Overview of phenotypic changes in cancer cells | ||
| 8) | Cell cycle and cancer | ||
| 9) | DNA damage response in cancer cells | ||
| 10) | DNA repair and cancer | ||
| 11) | Senescence aberrations in cancer cells | ||
| 12) | Apoptotic and autophagic aberrations in cancer cells | ||
| 13) | Invasive and metastatic abilities of cancer cells | ||
| 14) | Tumor heterogeneity and "cancer stem cells" | ||
| Course Notes: | The Molecular Basis of Cancer.2nd edition Author(s): Mendelsohn, Howley, Israel & Liotta. Publisher: W. B. Saunders Company, Philadelphia, 2011 |
| References: | The Genetic Basis of Human Cancer Author(s): B. Vogelstein & K. W. Kinzler Publisher: McGraw-Hill, New York, 1999 |
| Semester Requirements | Number of Activities | Level of Contribution |
| Attendance | 10 | % 5 |
| Laboratory | 0 | % 0 |
| Application | 0 | % 0 |
| Field Work | 0 | % 0 |
| Special Course Internship (Work Placement) | 0 | % 0 |
| Quizzes | 0 | % 0 |
| Homework Assignments | 1 | % 15 |
| Presentation | 0 | % 0 |
| Project | 0 | % 0 |
| Seminar | 0 | % 0 |
| Midterms | 1 | % 30 |
| Preliminary Jury | 0 | % 0 |
| Final | 1 | % 50 |
| Paper Submission | 0 | % 0 |
| Jury | 0 | % 0 |
| Bütünleme | % 0 | |
| Total | % 100 | |
| PERCENTAGE OF SEMESTER WORK | % 50 | |
| PERCENTAGE OF FINAL WORK | % 50 | |
| Total | % 100 | |
| Activities | Number of Activities | Duration (Hours) | Workload |
| Course Hours | 14 | 3 | 42 |
| Laboratory | 0 | 0 | 0 |
| Application | 0 | 0 | 0 |
| Special Course Internship (Work Placement) | 0 | 0 | 0 |
| Field Work | 0 | 0 | 0 |
| Study Hours Out of Class | 14 | 8 | 112 |
| Presentations / Seminar | 0 | 0 | 0 |
| Project | 0 | 0 | 0 |
| Homework Assignments | 0 | 0 | 0 |
| Quizzes | 0 | 0 | 0 |
| Preliminary Jury | 0 | 0 | 0 |
| Midterms | 1 | 2 | 2 |
| Paper Submission | 0 | 0 | 0 |
| Jury | 0 | 0 | 0 |
| Final | 1 | 2 | 2 |
| Total Workload | 158 | ||
| No Effect | 1 Lowest | 2 Low | 3 Average | 4 High | 5 Highest |
| Program Outcomes | Level of Contribution |