| MATHEMATICS (TURKISH, PHD) | |||||
| PhD | TR-NQF-HE: Level 8 | QF-EHEA: Third Cycle | EQF-LLL: Level 8 | ||
| Course Code | Course Name | Semester | Theoretical | Practical | Credit | ECTS |
| MBG4065 | Introduction to Stem Cells | Fall | 3 | 0 | 3 | 6 |
| The course opens with the approval of the Department at the beginning of each semester |
| Language of instruction: | En |
| Type of course: | Departmental Elective |
| Course Level: | |
| Mode of Delivery: | Face to face |
| Course Coordinator : | Dr. Öğr. Üyesi ELIZABETH HEMOND |
| Course Objectives: | In this course, student should learn about the basic biology of embryonic, adult and cancer stem cells, molecular mechanisms of self renewal, differentiation and plasticity, reproductive and therapeutic cloning, epigenetic changes associated with stem cells, use of stem cells in cell based therapies and its ethical considerations. |
|
The students who have succeeded in this course; 1. Have a general understanding on stem cell biology. 2. Learn the basic features of stem cells and discuss the related mechanisms beneath. 3. Understand the effects of stem cells on the epigenetic changes. 4. Discuss stem cell based therapies and the related ethical issues stem from the uses of those therapies. 5. Categorize the stem cells. |
| Basic biology of embryonic, adult and cancer stem cells. Molecular mechanisms of self renewal, differentiation and plasticity. Reproductive and therapeutic cloning. Epigenetic changes associated with stem cells. Use of stem cells in cell based therapies and its ethical considerations. |
| Week | Subject | Related Preparation | |
| 1) | Introduction and classification of stem cells | ||
| 2) | Basic biology of stem cells (self-renewal, pluripotency, plasticity, asymmetric division, niche) | ||
| 3) | Embryonic Stem Cells | ||
| 4) | Epiblast Stem Cells | ||
| 5) | Induced Pluripotent Stem Cells | ||
| 6) | Germline Stem Cells, Epigenetic Reprogramming I | ||
| 7) | Germline Stem Cells, Epigenetic Reprogramming II | ||
| 8) | Cancer Stem Cells | ||
| 9) | Mesenchymal Stem Cells | ||
| 10) | Hematopoeitic stem cells | ||
| 11) | Organ Specific Stem Cells (Neural- Vascular Endothelial, Pancreatic) | ||
| 12) | Organ Specific Stem Cells (Hepatic, Cardiac) | ||
| 13) | Organ Specific Stem Cells (Epidermal, Lung) | ||
| 14) | Review | ||
| Course Notes: | Weekly course notes will be provided |
| References: | Stem Cells Handbook, Steward Sell Publisher, 2003,ISBN 13: 9781588291134 |
| Semester Requirements | Number of Activities | Level of Contribution |
| Attendance | 10 | % 5 |
| Laboratory | 0 | % 0 |
| Application | 0 | % 0 |
| Field Work | 0 | % 0 |
| Special Course Internship (Work Placement) | 0 | % 0 |
| Quizzes | 0 | % 0 |
| Homework Assignments | 1 | % 15 |
| Presentation | 0 | % 0 |
| Project | 0 | % 0 |
| Seminar | 0 | % 0 |
| Midterms | 1 | % 30 |
| Preliminary Jury | 0 | % 0 |
| Final | 1 | % 50 |
| Paper Submission | 0 | % 0 |
| Jury | 0 | % 0 |
| Bütünleme | % 0 | |
| Total | % 100 | |
| PERCENTAGE OF SEMESTER WORK | % 50 | |
| PERCENTAGE OF FINAL WORK | % 50 | |
| Total | % 100 | |
| Activities | Number of Activities | Duration (Hours) | Workload |
| Course Hours | 14 | 3 | 42 |
| Laboratory | 0 | 0 | 0 |
| Application | 0 | 0 | 0 |
| Special Course Internship (Work Placement) | 0 | 0 | 0 |
| Field Work | 0 | 0 | 0 |
| Study Hours Out of Class | 14 | 8 | 112 |
| Presentations / Seminar | 0 | 0 | 0 |
| Project | 0 | 0 | 0 |
| Homework Assignments | 0 | 0 | 0 |
| Quizzes | 0 | 0 | 0 |
| Preliminary Jury | 0 | 0 | 0 |
| Midterms | 1 | 2 | 2 |
| Paper Submission | 0 | 0 | 0 |
| Jury | 0 | 0 | 0 |
| Final | 1 | 2 | 2 |
| Total Workload | 158 | ||
| No Effect | 1 Lowest | 2 Low | 3 Average | 4 High | 5 Highest |
| Program Outcomes | Level of Contribution |