| MATHEMATICS (TURKISH, PHD) | |||||
| PhD | TR-NQF-HE: Level 8 | QF-EHEA: Third Cycle | EQF-LLL: Level 8 | ||
| Course Code | Course Name | Semester | Theoretical | Practical | Credit | ECTS |
| BNG5111 | Concepts and Applications in Biomedical Engineering | Fall | 3 | 0 | 3 | 8 |
| The course opens with the approval of the Department at the beginning of each semester |
| Language of instruction: | En |
| Type of course: | Departmental Elective |
| Course Level: | |
| Mode of Delivery: | Face to face |
| Course Coordinator : | Prof. Dr. GÜLAY BULUT |
| Course Objectives: | Providing theoretical and practical information about the engineering aspects of biotechnological processes. |
|
The students who have succeeded in this course; 1) Ability to make necessary calculations regarding to yield and productivity 2) To take interest in new approaches of commercial applications of biotechnological processes. 3) Ability to understand the bioconversions and bioconversion kinetics. 4) Comprehend the importance and application range of microorganism, plant and animal cells in biotechnology applications. 5)Fundamental conception informations of microorganism, plant and animal cell culture techniques. |
| 1. Basic components of cell culture systems (Cell structure, cell growth, differentiation transformation, ageing) 2. Cell growth media (Basic composition of media, effect of culture system on medium design, medium preparation, sterilization, quality control) 3. Sources of the cell line cultures 4. Contamination of cell cultures Sources, concequences, prevention and elimination) 5. Plant cell and tissue cultures (Definitions, culture media and conditions) 6. Plant cell and tissue culture methods, application areas 7. Secondary metabolites produced by plant cell and tissue cultures 8. Callus cultures and in vitro selection 9. Bioprocess kinetics 10. Mathematical modeling and estimation of the performance 11. Definitions of yield and productivity 12. Types of biocatalysts 13. Bioreactors |
| Week | Subject | Related Preparation | |
| 1) | Basic components of cell culture systems (cell structure, cell growth, differentiation transformation, ageing). | ||
| 2) | Cell growth media (Basic composition of media, effect of culture system on medium design, medium preparation, sterilization, quality control). | ||
| 3) | Sources of the cell line cultures. | ||
| 4) | Contamination of cell cultures sources, concequences, prevention and elimination). | ||
| 5) | Plant cell and tissue cultures (definitions, culture media and conditions). | ||
| 6) | Secondary metabolites produced by plant cell and tissue cultures. | ||
| 7) | In vitro selection by plant cell and tissue cultures. | ||
| 8) | Production disease free plant material. | ||
| 9) | Mathematical modeling and estimation of the performance I | ||
| 10) | Mathematical modeling and estimation of the performance II | ||
| 11) | Types of biocatalysts. Definitions of yield and productivity I | ||
| 12) | Types of biocatalysts. Definitions of yield and productivity II | ||
| 13) | Bioreactors. Working systems of bioreactors I | ||
| 14) | Bioreactors. Working systems of bioreactors II | ||
| Course Notes: | Griffiths, J. B., 1990. Animal Cell Biotechnology, Vol 1-4; Eds. R. E. Spier, Acad. Pres Inc. Freshney I. R. 1994. Culture of Animal Cells. Wiley Liss Inc. Neumann, K., H., A.Kumar, J. Imani, 2009. Plant Cell and Tissue Culture – A Tool in Biotechnology; Basics and Application. Springer – Verlag , Berlin Heidelberg. George, E. F., M.A. Hall, G.-J.De Klerk, 2008. Plant Propagation by Tissue Culture. 3rd Edition Volume 1. Springer Publishing Company. Loyola-Vargas, V.M., F. Vázquez-Flota, 2006. Plant Cell Culture Protocols, Second Edition, Humana Press Inc. Bailey, J. E., D. F. Ollis, 1986. Biochemical Engineering Fundamentals, McGraw Hill. |
| References: | Related articles. İlgili makaleler. |
| Semester Requirements | Number of Activities | Level of Contribution |
| Attendance | 1 | % 10 |
| Laboratory | 0 | % 0 |
| Application | 0 | % 0 |
| Field Work | 0 | % 0 |
| Special Course Internship (Work Placement) | 0 | % 0 |
| Quizzes | 0 | % 0 |
| Homework Assignments | 0 | % 0 |
| Presentation | 0 | % 0 |
| Project | 0 | % 0 |
| Seminar | 0 | % 0 |
| Midterms | 1 | % 30 |
| Preliminary Jury | 0 | % 0 |
| Final | 1 | % 60 |
| Paper Submission | 0 | % 0 |
| Jury | 0 | % 0 |
| Bütünleme | % 0 | |
| Total | % 100 | |
| PERCENTAGE OF SEMESTER WORK | % 40 | |
| PERCENTAGE OF FINAL WORK | % 60 | |
| Total | % 100 | |
| Activities | Number of Activities | Duration (Hours) | Workload |
| Course Hours | 14 | 4 | 56 |
| Laboratory | 0 | 0 | 0 |
| Application | 0 | 0 | 0 |
| Special Course Internship (Work Placement) | 0 | 0 | 0 |
| Field Work | 0 | 0 | 0 |
| Study Hours Out of Class | 14 | 7 | 98 |
| Presentations / Seminar | 0 | 0 | 0 |
| Project | 0 | 0 | 0 |
| Homework Assignments | 0 | 0 | 0 |
| Quizzes | 0 | 0 | 0 |
| Preliminary Jury | 0 | 0 | 0 |
| Midterms | 1 | 20 | 20 |
| Paper Submission | 0 | 0 | 0 |
| Jury | 0 | 0 | 0 |
| Final | 1 | 30 | 30 |
| Total Workload | 204 | ||
| No Effect | 1 Lowest | 2 Low | 3 Average | 4 High | 5 Highest |
| Program Outcomes | Level of Contribution |