BIOENGINEERING (ENGLISH, THESIS)
Master TR-NQF-HE: Level 7 QF-EHEA: Second Cycle EQF-LLL: Level 7

Course Introduction and Application Information

Course Code Course Name Semester Theoretical Practical Credit ECTS
BNG5111 Concepts and Applications in Biomedical Engineering Fall 3 0 3 8
The course opens with the approval of the Department at the beginning of each semester

Basic information

Language of instruction: En
Type of course: Must Course
Course Level:
Mode of Delivery: Face to face
Course Coordinator : Prof. Dr. GÜLAY BULUT
Course Objectives: Providing theoretical and practical information about the engineering aspects of biotechnological processes.

Learning Outputs

The students who have succeeded in this course;
1) Ability to make necessary calculations regarding to yield and productivity
2) To take interest in new approaches of commercial applications of biotechnological processes.
3) Ability to understand the bioconversions and bioconversion kinetics.
4) Comprehend the importance and application range of microorganism, plant and animal cells in biotechnology applications.
5)Fundamental conception informations of microorganism, plant and animal cell culture techniques.

Course Content

1. Basic components of cell culture systems (Cell structure, cell growth, differentiation transformation, ageing) 2. Cell growth media (Basic composition of media, effect of culture system on medium design, medium preparation, sterilization, quality control) 3. Sources of the cell line cultures 4. Contamination of cell cultures Sources, concequences, prevention and elimination) 5. Plant cell and tissue cultures (Definitions, culture media and conditions) 6. Plant cell and tissue culture methods, application areas 7. Secondary metabolites produced by plant cell and tissue cultures 8. Callus cultures and in vitro selection 9. Bioprocess kinetics 10. Mathematical modeling and estimation of the performance 11. Definitions of yield and productivity 12. Types of biocatalysts 13. Bioreactors

Weekly Detailed Course Contents

Week Subject Related Preparation
1) Basic components of cell culture systems (cell structure, cell growth, differentiation transformation, ageing).
2) Cell growth media (Basic composition of media, effect of culture system on medium design, medium preparation, sterilization, quality control).
3) Sources of the cell line cultures.
4) Contamination of cell cultures sources, concequences, prevention and elimination).
5) Plant cell and tissue cultures (definitions, culture media and conditions).
6) Secondary metabolites produced by plant cell and tissue cultures.
7) In vitro selection by plant cell and tissue cultures.
8) Production disease free plant material.
9) Mathematical modeling and estimation of the performance I
10) Mathematical modeling and estimation of the performance II
11) Types of biocatalysts. Definitions of yield and productivity I
12) Types of biocatalysts. Definitions of yield and productivity II
13) Bioreactors. Working systems of bioreactors I
14) Bioreactors. Working systems of bioreactors II

Sources

Course Notes: Griffiths, J. B., 1990. Animal Cell Biotechnology, Vol 1-4; Eds. R. E. Spier, Acad. Pres Inc. Freshney I. R. 1994. Culture of Animal Cells. Wiley Liss Inc. Neumann, K., H., A.Kumar, J. Imani, 2009. Plant Cell and Tissue Culture – A Tool in Biotechnology; Basics and Application. Springer – Verlag , Berlin Heidelberg. George, E. F., M.A. Hall, G.-J.De Klerk, 2008. Plant Propagation by Tissue Culture. 3rd Edition Volume 1. Springer Publishing Company. Loyola-Vargas, V.M., F. Vázquez-Flota, 2006. Plant Cell Culture Protocols, Second Edition, Humana Press Inc. Bailey, J. E., D. F. Ollis, 1986. Biochemical Engineering Fundamentals, McGraw Hill.
References: Related articles. İlgili makaleler.

Evaluation System

Semester Requirements Number of Activities Level of Contribution
Attendance 1 % 10
Laboratory 0 % 0
Application 0 % 0
Field Work 0 % 0
Special Course Internship (Work Placement) 0 % 0
Quizzes 0 % 0
Homework Assignments 0 % 0
Presentation 0 % 0
Project 0 % 0
Seminar 0 % 0
Midterms 1 % 30
Preliminary Jury 0 % 0
Final 1 % 60
Paper Submission 0 % 0
Jury 0 % 0
Bütünleme % 0
Total % 100
PERCENTAGE OF SEMESTER WORK % 40
PERCENTAGE OF FINAL WORK % 60
Total % 100

ECTS / Workload Table

Activities Number of Activities Duration (Hours) Workload
Course Hours 14 4 56
Laboratory 0 0 0
Application 0 0 0
Special Course Internship (Work Placement) 0 0 0
Field Work 0 0 0
Study Hours Out of Class 14 7 98
Presentations / Seminar 0 0 0
Project 0 0 0
Homework Assignments 0 0 0
Quizzes 0 0 0
Preliminary Jury 0 0 0
Midterms 1 20 20
Paper Submission 0 0 0
Jury 0 0 0
Final 1 30 30
Total Workload 204

Contribution of Learning Outcomes to Programme Outcomes

No Effect 1 Lowest 2 Low 3 Average 4 High 5 Highest
           
Program Outcomes Level of Contribution
1) An understanding of the advanced concepts of Mathematics (calculus, analysis, linear algebra, differential equations, statistics), Natural Sciences (physics, chemistry, biology), and Engineering Sciences (electronics, material science, mechanics, thermal and fluid systems, control, signal and image processing, microcontrollers) relevant to Biomedical Engineering. 5
2) An ability to use at an advanced level the techniques, skills, and modern engineering tools (including software) necessary for engineering practice. 5
3) The capability of designing and conducting advanced experiments and of analyzing and evaluating data. 5
4) An ability to design the components of complex systems and processes under realistic constraints. 4
5) Acquisition of the skills needed to develop products (device, system, process) which are used in diagnosis, prevention, treatment and cure of diseases. 4
6) An ability to communicate knowledge and opinion efectively, both oral and in writing. 5
7) An ability to assume initiative and individual resposibility, and to cooperate with team-mates from other disciplines. 3
8) A kowledge of the current needs and problems of society, and an awareness of the social and global impact of engineering solutions. 3
9) Assimilation of the ethics and responsibilities of the profession. 5
10) Recognition of the importance of life-long learning, and participation therein. 4