INDUSTRIAL ENGINEERING
Bachelor TR-NQF-HE: Level 6 QF-EHEA: First Cycle EQF-LLL: Level 6

Course Introduction and Application Information

Course Code Course Name Semester Theoretical Practical Credit ECTS
MBG4066 Cancer Genetics and Biology Fall 3 0 3 6
This catalog is for information purposes. Course status is determined by the relevant department at the beginning of semester.

Basic information

Language of instruction: English
Type of course: Non-Departmental Elective
Course Level: Bachelor’s Degree (First Cycle)
Mode of Delivery: Face to face
Course Coordinator : Assist. Prof. DİLEK ÇEVİK
Course Objectives: The course will provide the student with a comprehensive insight into the molecular biology and genetics of cancer with an awareness of the complexity of cancer biology. Lectures will primarily focus on the role of growth factors, oncogenes, tumor suppressor and cell stress mechanisms such as apoptosis, senescence, and autophagy. The fundamental principles behind cancer diagnosis, prevention, and targeted molecular therapy will also be discussed. Recent articles regarding cancer will be studied and students will present a subject of interest regarding cancer.

Learning Outcomes

The students who have succeeded in this course;
1. Understand the molecular and cellular mechanisms leading to cancer.
2. Describe the genetic event causing oncogenesis.
3. Discuss hallmarks of cancer and cellular stress mechanisms.
4. Discuss cell cycle, apoptosis, and multicellular interactions in cancer.
5. Describe the fundamental principles behind molecular cancer diagnosis.
6. Have an overview of methodologies used in cancer research.
7. Read and discuss cancer related research articles.

Course Content

Genetic changes in cancer, phenotype of cancer cells, oncogenes, tumor suppressor genes, hereditary cancers, cell cycle, apoptosis, senescence, DNA repair and cancer, multicellular interactions in cancer.

Weekly Detailed Course Contents

Week Subject Related Preparation
1) Cancer Epidemiology and Terminology Reading the Chapter notes
2) The Nature of Cancer Reading the chapter notes
3) Cancer as an Infectious Disease Reading the chapter notes
4) Oncogenes Reading the chapter notes
5) Tumor Suppressor Genes Reading the chapter notes
6) pRB and Control of Cell Cycle Clock Reading the chapter notes
7) p53 and Cancer Reading the chapter notes
8) DNA damage response in cancer cells Reading the chapter notes
10) DNA repair and cancer Reading the chapter notes
11) Senescence aberrations in cancer cells Reading the chapter notes
12) Apoptotic and autophagic aberrations in cancer cells Reading the chapter notes
13) Article Discussions and Student presentations Reading the articles to be presented before class.
14) Article Discussions and Student presentations Reading the articles to be presented before class.

Sources

Course Notes / Textbooks: Course Book: The Biology of Cancer, 3rd Edition by Robert Weinberg.
Öğrencilere okuma materyali olarak bilimsel makaleler verilecektir.
References: Course Book: The Biology of Cancer, 3rd Edition by Robert Weinberg.
Scientific articles will also be assigned to students as reading material.

Evaluation System

Semester Requirements Number of Activities Level of Contribution
Homework Assignments 1 % 5
Presentation 1 % 10
Midterms 1 % 30
Final 1 % 50
Paper Submission 1 % 5
Total % 100
PERCENTAGE OF SEMESTER WORK % 50
PERCENTAGE OF FINAL WORK % 50
Total % 100

ECTS / Workload Table

Activities Number of Activities Duration (Hours) Workload
Course Hours 14 3 42
Study Hours Out of Class 14 4 56
Presentations / Seminar 1 10 10
Project 1 10 10
Homework Assignments 1 10 10
Midterms 1 3 3
Paper Submission 1 10 10
Final 1 3 3
Total Workload 144

Contribution of Learning Outcomes to Programme Outcomes

No Effect 1 Lowest 2 Low 3 Average 4 High 5 Highest
           
Program Outcomes Level of Contribution
1) Build up a body of knowledge in mathematics, science and industrial engineering subjects; use theoretical and applied information in these areas to model and solve complex engineering problems.
2) Identify, formulate, and solve complex engineering problems; select and apply proper analysis and modeling methods for this purpose.
3) Design a complex system, process, device or product under realistic constraints and conditions, in such a way as to meet the desired result; apply modern design methods for this purpose. The ability to apply modern design methods to meet this objective.
4) Devise, select, and use modern techniques and tools needed for solving complex problems in industrial engineering practice; employ information technologies effectively.
5) Design and conduct experiments, collect data, analyze and interpret results for investigating the complex problems specific to industrial engineering.
6) Cooperate efficiently in intra-disciplinary and multi-disciplinary teams; and show self-reliance when working independently.
7) Demonstrate effective communication skills in both oral and written English and Turkish. Writing and understanding reports, preparing design and production reports, making effective presentations, giving and receiving clear and understandable instructions.
8) Recognize the need for lifelong learning; show ability to access information, to follow developments in science and technology, and to continuously educate him/herself. 3
9) Develop an awareness of professional and ethical responsibility, and behaving accordingly. Information about the standards used in engineering applications.
10) Know business life practices such as project management, risk management, and change management; develop an awareness of entrepreneurship, innovation, and sustainable development. 4
11) Know contemporary issues and the global and societal effects of modern age engineering practices on health, environment, and safety; recognize the legal consequences of engineering solutions.
12) Develop effective and efficient managerial skills.