MEDICINE
Bachelor TR-NQF-HE: Level 6 QF-EHEA: First Cycle EQF-LLL: Level 6

Course Introduction and Application Information

Course Code Course Name Semester Theoretical Practical Credit ECTS
MED3009 Research Methodology and Biostatistics Fall 1 2 2 4

Basic information

Language of instruction: English
Type of course: Must Course
Course Level: Bachelor’s Degree (First Cycle)
Mode of Delivery:
Course Coordinator : Dr. Öğr. Üyesi MELİKE YAVUZ
Recommended Optional Program Components: Hastane ziyaretleri
Course Objectives: This course aims to introduce pharmacogenetics and pharmacogenomics

Learning Outcomes

The students who have succeeded in this course;
At the end of this course, students will:
● Explain the basic principles of human genetics and heredity as they apply to inter-individual variation in treatment response.
● Apply the principles of molecular and cellular biology to explain the genetic basis of variability in drug response.
● Discuss how genetic variability in genes encoding drug metabolizing enzymes, drug transporting proteins, and drug receptors (targets) can contribute to variability in drug disposition and action, leading to changes in pharmacokinetics, pharmacodynamics, and clinical outcome.
● Discuss impact of pharmacogenomics in different therapeutic areas.
● Discuss case studies reporting the clinical consequences of pharmacogenomics on therapeutic efficacy or toxicity.
● Apply pharmacogenomic concepts to a particular drug therapy to solve relevant problems in pharmaceutical care.
● Recognize the societal and ethical implications of genetic testing and the resultant individualization of drug therapy.
● Critically evaluate the current and future literature in the area of pharmacogenomics.
● Identify key sources and reliable databases with pharmacogenomics knowledge base.

Course Content

The genetic basis of variability in drug response can contribute to drug efficacy and toxicity, adverse drug reactions and drug-drug interaction. As such, physicians need a thorough understanding of the genetic component of patient variability to deliver effective individualized pharmaceutical care. Understanding of the basics of pharmacogenomics will enable students to better understand and manage the new genomics based diagnostic tools as they become available as well as make best treatment choices. The principles covered in this course will soon become part of clinical care, such that a well-trained physician will need to know how to critically evaluate, interpret, and apply this information on a daily basis.

Weekly Detailed Course Contents

Week Subject Related Preparation
1) Relationship to pharmacokinetics and pharmacodynamics, pharmacogenetics in drug metabolism: role of phase I enzymes, cytochromes p450, Pharmacogenetics of phase II drug metabolizing enzymes, pharmacogenetics of drug transporters, pharmacogenetics of drug targets -
2) Cardiovascular pharmacogenetics, pharmacogenetics in psychiatry, pharmacogenetics in cancer, pharmacogenetics in asthma and COPD, pharmacogenetics of adverse drug reactions, -
3) Pharmacogenomics of inflammatory bowel diseases, pharmacogenetics of pain medication Ethical and social issues in pharmacogenomics testing -
4) High-throughput genotyping Technologies for pharmacogenetics, developments in analyses in pharmacogenetic datasets Exam -

Sources

Course Notes / Textbooks: Pharmacogenetics and Individualized therapy, Zee, Anke-Hilse Maitland-van der, Ann K.
Politics in of personalized medicine: Pharmacogenetic in the clinic, Hedgecoe, Adam Rose, Nicolas rabinow, Paul
Pharmacogenemics in Clinical Therapeutics, Dasgupta, Amitava, Langman, Loralie
References: -

Evaluation System

Semester Requirements Number of Activities Level of Contribution
Final 1 % 100
Total % 100
PERCENTAGE OF SEMESTER WORK % 0
PERCENTAGE OF FINAL WORK % 100
Total % 100

ECTS / Workload Table

Activities Number of Activities Duration (Hours) Workload
Course Hours 20 1 20
Application 20 3 60
Study Hours Out of Class 12 1 12
Final 1 2 2
Total Workload 94

Contribution of Learning Outcomes to Programme Outcomes

No Effect 1 Lowest 2 Low 3 Average 4 High 5 Highest
           
Program Outcomes Level of Contribution
1) Integrates the knowledge, skills and attitudes acquired from basic and clinical medical sciences, behavioral sciences and social sciences, and uses them in health service delivery.
2) In patient management, shows a biopsychosocial approach that takes into account the socio-demographic and sociocultural background of the individual, regardless of language, religion, race and gender.
3) In the provision of health services, prioritizes the protection and development of the health of individuals and society.
4) Taking into account the individual, societal, social and environmental factors affecting health; does the necessary work to maintain and improve the state of health.
5) By recognizing the characteristics, needs and expectations of the target audience, provides health education to healthy/sick individuals and their relatives and other healthcare professionals.
6) Shows a safe, rational and effective approach in health service delivery, prevention, diagnosis, treatment, follow-up and rehabilitation processes.
7) Performs invasive and/or non-invasive procedures in diagnosis, treatment, follow-up and rehabilitation processes in a safe and effective way for the patient.
8) Provides health services by considering patient and employee health and safety.
9) In the provision of health services, takes into account the changes in the physical and socioeconomic environment on a regional and global scale, as well as the changes in the individual characteristics and behaviors of the people who apply to it.
10) Takes good medical practice into account while carrying out his/her profession.
11) Fulfills its duties and obligations within the framework of ethical principles, rights and legal responsibilities required by its profession.
12) Demonstrates decisive behavior in providing high-quality health care, taking into account the integrity of the patient.
13) Evaluates his/her performance in his/her professional practice by considering his/her emotions and cognitive characteristics.
14) Advocates improving the provision of health services by considering the concepts of social reliability and social responsibility for the protection and development of public health.
15) Can plan and carry out service delivery, training and consultancy processes related to individual and community health in cooperation with all components for the protection and development of health.
16) Evaluates the impact of health policies and practices on individual and community health indicators and advocates increasing the quality of health services.
17) The physician attaches importance to the protection of his/her own physical, mental and social health, and does what is necessary for this
18) Shows exemplary behavior and leads the healthcare team during service delivery.
19) Uses resources cost-effectively, for the benefit of society and in accordance with the legislation, in the planning, implementation and evaluation processes of health services in the health institution he/she is the manager of.
20) Establishes positive communication within the health team it serves and assumes different team roles when necessary.
21) Is aware of the duties and responsibilities of the health workers in the health team and acts accordingly.
22) In the professional practices, works in harmony and effectively with the colleagues and other professional groups.
23) Communicates effectively with patients, their relatives, healthcare professionals, other professional groups, institutions and organizations.
24) Communicates effectively with individuals and groups that require a special approach and have different socio-cultural characteristics.
25) In the diagnosis, treatment, follow-up and rehabilitation processes, shows a patient-centered approach that associates the patient with the decision-making mechanisms.
26) Plans and implements scientific research, when necessary, for the population it serves, and uses the results and/or the results of other research for the benefit of the society.
27) Reaches and critically evaluates current literature knowledge about his/her profession.
28) Applies the principles of evidence-based medicine in clinical decision making.
29) Uses information technologies to increase the effectiveness of its work on health care, research and education.
30) Effectively manages individual work processes and career development.
31) Demonstrates skills in acquiring and evaluating new knowledge, integrating it with existing knowledge, applying it to professional situations and adapting to changing conditions throughout professional life.
32) Selects the right learning resources to improve the quality of the health service it offers, organizes its own learning process