| BIOMEDICAL ENGINEERING | |||||
| Bachelor | TR-NQF-HE: Level 6 | QF-EHEA: First Cycle | EQF-LLL: Level 6 | ||
| Course Code | Course Name | Semester | Theoretical | Practical | Credit | ECTS |
| BME4506 | Cell and Tissue Engineering | Spring | 2 | 2 | 3 | 7 |
| This catalog is for information purposes. Course status is determined by the relevant department at the beginning of semester. |
| Language of instruction: | English |
| Type of course: | Departmental Elective |
| Course Level: | Bachelor’s Degree (First Cycle) |
| Mode of Delivery: | Face to face |
| Course Coordinator : | Assist. Prof. CANAN BAĞCI |
| Course Objectives: | Upon successful completion of this course, the student will be able to: - Describe the principals of cell and tissue engineering - Describe the fundamental patterns of growth and differentiation - Explain the concepts of in vitro control of tissue development - Explain the concepts of in vivo synthesis of tissues and organs - Define different types of biomaterials used in tissue engineering - Describe the transplantation process for engineered cells and tissues. - Explain the stem cell and gene therapy concepts. |
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The students who have succeeded in this course; - Describe the principals of cell and tissue engineering - Describe the fundamental patterns of growth and differentiation - Explain the concepts of in vitro control of tissue development - Explain the concepts of in vivo synthesis of tissues and organs - Define different types of biomaterials used in tissue engineering - Describe the transplantation process for engineered cells and tissues. - Explain the stem cell and gene therapy concepts. |
| This course provides an in-depth introduction to the principles of cell and tissue engineering, covering fundamental concepts of cell growth, differentiation, and tissue development. Students will explore in vitro and in vivo approaches to tissue synthesis, the role of biomaterials, and transplantation techniques, stem cell applications, gene therapy, and emerging trends such as 3D bioprinting and regenerative medicine. Teaching methods and techniques used in the course are lecture, reading, discussion, individual study, student presentations and laboratory experiments. |
| Week | Subject | Related Preparation |
| 1) | Introduction to Cell and Tissue Engineering | Lecture Notes |
| 2) | The Basis of Growth and Differentiation -1 | Lecture Notes |
| 3) | The Basis of Growth and Differentiation -2 | Lecture Notes |
| 4) | In vitro Control of Tissue Development | Lecture Notes |
| 5) | In vivo Synthesis of Tissues and Organs - 1 / Lab session #1 Basic information about cell culture lab | Lecture Notes |
| 6) | In vivo Synthesis of Tissues and Organs - 2 / Lab session #2 Pipetting, handling of the equipments | Lecture Notes |
| 7) | Biomaterials in Tissue Engineering - 1 / Lab session #3 Cell counting, changing the media | Lecture Notes |
| 8) | Biomaterials in Tissue Engineering -2 | Lecture Notes |
| 9) | Biomaterials in Tissue Engineering - 3 / Lab session #4 Subculturing | Lecture Notes |
| 10) | Transplantation of Engineered Cells and Tissues / Lab session #5 MTT cytotoxicity assay | Lecture Notes |
| 11) | Stem Cells / Lab session #6 Biocompatible scaffolds | Lecture Notes |
| 12) | Gene Therapy | Lecture Notes |
| 13) | Student Presentations | |
| 14) | Student Presentations |
| Course Notes / Textbooks: | 1. Ders notları 2. Principles of Tissue Engineering, Robert Lanza, Robert Langer, Joseph Vacanti, Anthony Atala. 5th edition. |
| References: | 1. Lecture Notes 2. Principles of Tissue Engineering, Robert Lanza, Robert Langer, Joseph Vacanti, Anthony Atala. 5th edition. |
| Semester Requirements | Number of Activities | Level of Contribution |
| Laboratory | 6 | % 15 |
| Presentation | 1 | % 15 |
| Midterms | 1 | % 30 |
| Final | 1 | % 40 |
| Total | % 100 | |
| PERCENTAGE OF SEMESTER WORK | % 60 | |
| PERCENTAGE OF FINAL WORK | % 40 | |
| Total | % 100 | |
| Activities | Number of Activities | Duration (Hours) | Workload |
| Course Hours | 14 | 2 | 28 |
| Laboratory | 6 | 2 | 12 |
| Study Hours Out of Class | 14 | 8 | 112 |
| Presentations / Seminar | 1 | 8 | 8 |
| Midterms | 1 | 1 | 1 |
| Final | 1 | 1 | 1 |
| Total Workload | 162 | ||
| No Effect | 1 Lowest | 2 Low | 3 Average | 4 High | 5 Highest |
| Program Outcomes | Level of Contribution | |
| 1) | Adequate knowledge of subjects specific to mathematics (analysis, linear, algebra, differential equations, statistics), science (physics, chemistry, biology) and related engineering discipline, and the ability to use theoretical and applied knowledge in these fields in complex engineering problems. | |
| 2) | Identify, formulate, and solve complex Biomedical Engineering problems; select and apply proper modeling and analysis methods for this purpose | 2 |
| 3) | Design complex Biomedical systems, processes, devices or products under realistic constraints and conditions, in such a way as to meet the desired result; apply modern design methods for this purpose. | 3 |
| 4) | Devise, select, and use modern techniques and tools needed for solving complex problems in Biomedical Engineering practice; employ information technologies effectively. | 5 |
| 5) | Design and conduct numerical or physical experiments, collect data, analyze and interpret results for investigating the complex problems specific to Biomedical Engineering. | 4 |
| 6) | Cooperate efficiently in intra-disciplinary and multi-disciplinary teams; and show self-reliance when working on Biomedical Engineering-related problems. | 5 |
| 7) | Ability to communicate effectively in Turkish, oral and written, to have gained the level of English language knowledge (European Language Portfolio B1 general level) to follow the innovations in the field of Biomedical Engineering; gain the ability to write and understand written reports effectively, to prepare design and production reports, to make effective presentations, to give and receive clear and understandable instructions. | 4 |
| 8) | Recognize the need for life-long learning; show ability to access information, to follow developments in science and technology, and to continuously educate oneself. | 3 |
| 9) | Having knowledge for the importance of acting in accordance with the ethical principles of biomedical engineering and the awareness of professional responsibility and ethical responsibility and the standards used in biomedical engineering applications | |
| 10) | Learn about business life practices such as project management, risk management, and change management; develop an awareness of entrepreneurship, innovation, and sustainable development. | 3 |
| 11) | Acquire knowledge about the effects of practices of Biomedical Engineering on health, environment, security in universal and social scope, and the contemporary problems of Biomedical Engineering; is aware of the legal consequences of Mechatronics engineering solutions. | 5 |